Lymphoma
The following table illustrates the two most commonly used classifications plus an older classification. Because of differences in how the lymphomas are described, there is not a one-to-one comparison between the systems, and a single disease could be known by multiple names.
Comparison of Some Non-Hodgkin Lymphoma Classifications
| NCI* (Working Formulation) (Older Classification) | REAL** | WHO*** Classification |
|---|---|---|
| B cell lineage/NHL | Mature B cell lymphoma |
|
| Low grade lymphoma Small lymphocytic lymphoma (plasmacytoid) Follicular lymphoma (small cleaved cell, large cell, mixed cell) |
B-cell chronic lymphocytic leukemia Lymphoplasmacytic lymphoma Nodal and extranodal marginal B-cell lymphoma Follicular Center, grades I, II, and III lymphoma Mantle Cell lymphoma |
B cell CLL / SLL Splenic marginal zone B-cell lymphoma Extranodal marginal B cell lymphoma Follicular lymphoma Mantle cell lymphoma Diffuse large B-cell lymphoma Burkitt’s lymphoma |
| T and NK Cell Neoplasms | T and NK Cell Neoplasms | |
| Mature T cell lymphoma | ||
| Small lymphocyte lymphoma Mycosis Fungoides Diffuse lymphoma (small cleaved, large, mixed cell) Large cell immunoblastic lymphoma |
Adult T cell lymphoma Mycosis fungoides Anaplastic large cell lymphoma not otherwise characterized Immunoblastic T cell lymphoma |
|
| Langerhans cell histiocytosis Langerhans cell sarcoma Interdigitating dendritic cell sarcoma/tumor Follicular dendritic cell sarcoma/tumor Dendritic cell sarcoma, not otherwise specified |
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| * NCI = National Cancer Institute ** REAL = Revised European American Lymphoma *** WHO = World Health Organization |
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