Bone marrow disorder symptoms may be severe and life threatening or very subtle. Some chronic conditions may be discovered during yearly physical examinations, while other acute conditions cause symptoms related to too many or too few functioning blood cells. These symptoms include:

• Fever
• Weakness, fatigue, and pallor due to anemia
• Weight loss
• Swollen lymph nodes, liver, spleen, kidneys, and testicles
• Bleeding and bruising
• Night sweats
• Bone and joint pain
• Frequent infections
• Headaches, vomiting, confusion, and seizures (may occur when cells are increaed in the brain or central nervous system)