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Factor V Leiden Mutation
and PT 20210 Mutation

Article Sources

NOTE: This article is based on research that utilizes the sources cited here as well as the collective experience of the Lab Tests Online Editorial Review Board. This article is periodically reviewed by the Editorial Board and may be updated as a result of the review. Any new sources cited will be added to the list and distinguished from the original sources used.

We have included the web address to online sources used in developing and reviewing this article for documentation purposes only. Links included on this Sources page are valid, working links at the time they are posted. Please be aware that the source owner may, from time to time, reorganize the source web site, which can result in broken links on our pages. If you wish to access a source and come across a broken link, you may still be able to access it by entering just the parent web address in your browser's address bar (eg, "www.nih.gov") and then by entering the source title in the site's search feature.

S1
Thomas, Clayton L., Editor (1997). Taber’s Cyclopedic Medical Dictionary. F.A. Davis Company, Philadelphia, PA [18th Edition].

S2
Pagana, Kathleen D. & Pagana, Timothy J. (2001). Mosby’s Diagnostic and Laboratory Test Reference 5th Edition: Mosby, Inc., Saint Louis, MO.

S3
Coagulation Test Panels [7 paragraphs]. Florida Hospital Cancer Institute, Clinical and Research Laboratories [Online information]. Available FTP: http://www.fhci-labs.com/researchlabs/clinicallabs/hemostasisandthrombosis/panels.htm

S4
Confusing Coagulation Test Names [6 paragraphs], UAB Coagulation Service, Univ of Alabama at Birmingham [Online information]. Available FTP: http://peir.path.uab.edu/coag/article_187.shtml
Online test menu and information: http://peir.path.uab.edu/coag/cat_index_14.shtml
Activated Protein C Resistance (Screen for Factor V Leiden)
Factor V Leiden Mutation
Prothrombin Mutation 20210

S5
Check, W. (1999 September). Labs Home In On Mutant Alleles [54 paragraphs]. CAP Today, In the News [On-line Journal]. Available FTP: http://www.cap.org/captoday/archive/1999/cov999.html

S6
Chapter 132 Thrombotic Disorders, General [20 paragraphs]. The Merck Manual of Diagnosis and Therapy, Section 11. Hematology And Oncology [Online information]. Available FTP: http://www.merck.com/pubs/mmanual/section11/chapter132/132a.htm

S7
Laposata, M. & Vancott, E. (2000 January). How to work up hypercoagulability [6 paragraphs]. CAP In the News [On-line Coagulation Case Study]. Available FTP: http://www.cap.org/CAPToday/casestudy/coag5.html

S8
Factor V Leiden [14 paragraphs]. University of Illinois - Urbana/Champaign, Carle Cancer Center, Hematology Resource Page, Patient Resources [On-line information]. Available FTP: http://www-admin.med.uiuc.edu/hematology/PtFacV2.htm

S9
Ronald C. McGlennen, R. and Key, N. ( ). Clinical and Laboratory Management of the Prothrombin G20210A Mutation [11 paragraphs]. College of American Pathologists, Practicing Pathology [On-line article]. Available online

S10
Prothrombin Gene Mutation 20210A [11 paragraphs]. University of Illinois - Urbana/Champaign, Carle Cancer Center, Hematology Resource Page, Patient Resources [On-line information]. Available FTP: http://www-admin.med.uiuc.edu/hematology/PtProthrombin.htm

S11
Press, R. et. al. (2002). Clinical Utility of Factor V Leiden (R506Q) Testing for the Diagnosis and Management of Thromboembolic Disorders [70 paragraphs] Arch Pathol Lab Med 126: 1304-1318 [Online pdf of journal article]. Available FTP: http://www.access-genetics.com/Arch_Pathol_Lab_Med_Vol%20126_Nov_2002_3.pdf

S12
(2001 January 10, Modified). Coagulation Test Descriptions, Factor V Leiden (Activated Protein C Resistance Pcr Assay) and Prothrombin (G20210A) Gene Polymorphism (PTG G20210A). Clinical Coagulation Laboratory, A division of Duke University Regional Referral Laboratory Services [Online information]. Available FTP: http://pathology.mc.duke.edu/coag/TestDes.htm

S13
Menta, S. (1999 Spring). The Coagulation Cascade [148 paragraphs]. Physiology Disorders Evaluation, College of Medicine, Univ of Florida [On-line information]. Available FTP: http://www.medinfo.ufl.edu/year2/coag/title.html

S14
Bauer, K. (2001). The Thrombophilias: Well-Defined Risk Factors with Uncertain Therapeutic Implications [20 paragraphs]. Ann Intern Med. 2001;135:367-373 [Journal]. Online at http://www.annals.org

S15
DeLoughery, T. (1999 March 15). Tests of Hemostasis and Thrombosis [66 paragraphs]. OHSU [Online student handout]. Available FTP: http://www.ohsu.edu/som-hemonc/handouts/deloughery/printtest.html

S16
Pagana, Kathleen D. & Pagana, Timothy J. (© 2007). Mosby’s Diagnostic and Laboratory Test Reference 8th Edition: Mosby, Inc., Saint Louis, MO. Pp 430-431.

S17
Clarke, W. and Dufour, D. R., Editors (2006). Contemporary Practice in Clinical Chemistry. AACC Press, Washington, DC. Harris, N. et. al. Chapter 19: Assessment of Hemostasis in the Clinical Laboratory pp 227-239.

S18
Kujovich, J. (2007 February 12, Update). Factor V Leiden Thrombophilia [55 pages]. GENEReviews [On-line information]. Accessed on: 3/14/07 Available FTP: http://www.genetests.org/query?dz=factor-v-leiden

S19
Kujovich, J. (2006 July 25). Prothrombin Thrombophilia [52 pages]. GENEReviews [On-line information]. Accessed on: 3/16/07 Available online

S20
Ornstein, D. and Cushman, M. (2003). Factor V Leiden [17 paragraphs]. Circulation 2003:107;94-97 [On-line information]. Accessed on: 3/14/07 Available FTP: http://circ.ahajournals.org/cgi/reprint/107/15/e94.pdf

S21
University of Illinois—Urbana/Champaign, Carle Cancer Center. Patient information on Factor V Leiden. Accessed on: June 2007 Available FTP: http://www-admin.med.uiuc.edu/hematology/PtFacV2.htm

S22
McPherson R, Pincus M, eds, (2007) Henry’s Clinical Diagnosis and Management by Laboratory Methods, 21st edition, Saunders Elsevier.



This article was last reviewed on August 8, 2007.


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