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AMA
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The Test Sample
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What is being tested?This test measures the amount of antimitochondrial antibodies (AMA) in the blood. The production of AMA is strongly associated with primary biliary cirrhosis (PBC). PBC is an autoimmune disorder that causes inflammation and scarring of the bile ducts inside the liver. It is found most frequently in women between the ages of 35 and 60. PBC blocks the flow of bile and causes progressive liver damage. About 94% of those affected by PBC will have significant concentrations of antimitochondrial antibodies.
There are several types of AMA designated as M1, M2, M3, M5, and M6. The M2 type has been found to be the most strongly associated with PBC, while the others may also be found in other conditions. Some laboratories have started to offer the AMA-M2 instead of the AMA, which tests for all types together.
How is the sample collected for testing?
A blood sample is obtained by inserting a needle into a vein in the arm.
NOTE: If undergoing medical tests makes you or someone you care for anxious, embarrassed, or even difficult to manage, you might consider reading one or more of the following articles: Coping with Test Pain, Discomfort, and Anxiety, Tips on Blood Testing, Tips to Help Children through Their Medical Tests, and Tips to Help the Elderly through Their Medical Tests.
Another article, Follow That Sample, provides a glimpse at the collection and processing of a blood sample and throat culture.
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This article was last reviewed on
December 21, 2005
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