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5-HIAA
Also known as: 5-hydroxyindoleacetic acid, HIAA, Serotonin metabolite
Formal name: 5-hydroxyindoleacetic acid
Related tests: Serotonin, Chromogranin A
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Common Questions
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1. Are there other metabolites of serotonin?
2. Can I do the 5-HIAA urine test at home?
3. Will my results be accurate if I must continue to take my medication?
4. Are some people at a higher risk for developing a carcinoid tumor?
1. Are there other metabolites of serotonin?
Yes, the other major metabolite is 5-hydroxytryptphol (5-HTOL). This substance is not routinely tested for but may sometimes be performed in a ratio with the 5-HIAA test to evaluate ethyl alcohol ingestion. An increased ratio of 5-HTOL/5-HIAA can be indicative of alcohol consumption in both living people and postmortem.
2. Can I do the 5-HIAA urine test at home?
No, this test requires specialized equipment and must be performed in a laboratory. Not every laboratory will perform this assay; in some cases, your sample will need to be sent to a reference laboratory.
3. Will my results be accurate if I must continue to take my medication?
If the drug is one that can increase or decrease the amount of serotonin and 5-HIAA, then your results may be affected. However, it is up to your doctor and you to decide whether or not your medication can be safely stopped prior to and during the test collection. If your drugs must be taken, then your doctor will interpret the test results with this in mind.
4. Are some people at a higher risk for developing a carcinoid tumor?
Anyone at any age can develop a carcinoid tumor but, according to the American Cancer Society, the average age at diagnosis is usually about 55 to 65. Patients with a family history of multiple endocrine neoplasia (MEN1), a genetic condition that increases a patient's risk of developing tumors in the endocrine system glands, may be at higher risk for developing a carcinoid tumor.
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This article was last reviewed on
June 12, 2006
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